The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules
نویسندگان
چکیده
منابع مشابه
The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules
Tubular cell apoptosis is a major phenotype of cell death in various forms of acute kidney injury. Quantifying apoptosis in fixed tissues is problematic because apoptosis evolves over time and dead cells are rapidly cleared by the phagocytic system. Phiphilux is a fluorescent probe that is activated specifically by caspase 3 and does not inhibit the subsequent activity of this effector caspase....
متن کاملGlucose transport by proximal renal tubules.
TUNE, BRUCE M., AND MAURICE B. BURG. Glucose transport by proximal renal tubuler. Am. J. Physiol. 221(Z) : 580-585. 197 1 .-Glucose transport was studied in isolated, perfused rabbit proximal renal tubules. Glucose was actively transported out of the lumen of both the convoluted and straight portions. The rate of glucose transport was, however, much greater in the convoluted portion than in the...
متن کاملActivated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Proteolysis of mutant huntingtin is crucial to the development of Huntington disease (HD). Specifically preventing proteolysis at the capase-6 (C6) consensus sequence at amino acid 586 of mutant huntingtin prevents the development of behavioural, motor and neuropathological features in a mouse model of HD. However, the mechanism underlying the selective toxicity of the 586 amino acid cleavage e...
متن کاملElectrophysiology of ammonia transport in renal straight proximal tubules.
To test for electrogenic transport of ammonium ions in straight proximal renal tubules, isolated perfused tubules have been exposed to peritubular ammonium ions during continuous recording of cell membrane potential. As a result, 20 mmol/liter NH4+ leads to a rapid, reversible depolarization of the cell membrane by 9.0 +/- 0.3 mV (N = 86). This depolarization is not significantly affected by 10...
متن کاملCyclophilin B expression in renal proximal tubules of hypertensive rats.
Rat cyclophilin-like protein (Cy-LP) is a candidate hypertension gene initially identified by differential hybridization and implicated in renal mechanisms of salt retention and high blood pressure. We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and an allele-specific polymerase chain reaction primer assay, that CypB but not Cy-LP...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IntraVital
سال: 2015
ISSN: 2165-9087
DOI: 10.1080/21659087.2015.1067352